田金洲 解恒革 秦斌 樊东升 卢涛 时晶 倪敬年 王鲁宁 王荫华

代表中国老年保健协会 阿尔茨海默病分会研究小组

Dementia screening and diagnostic framework in Chinese population 

Tian Jinzhou*, Xie Hengge,Qin Bin, Fan Dongsheng, Lu Tao, Shi Jing, Ni Jingnian, Wang Luning, Wang Yinhua; The Research Group of Alzheimer′s Disease Chinese. *Neurology Center, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China

Corresponding author: Tian Jinzhou, Email: jztian@hotmail.com

【Summary】There are no standard diagnostic criteria for Alzheimer′s disease (AD) in China. The copied international criteria has led to a high rate of missed diagnosis due to issues such as translation and cultural discrepancy. Under the principles of semantic equivalence, content equivalence and performance equivalence, the research group of Alzheimer′s Disease Chinese ( ADC) adopted several effective methods, such as two-way translation, content conversion, performance evaluation, etc. to systematically study the cognitive, behavioral, functional, and general assessment techniques in dementia screening and diagnosis, as well as their screening thresholds and diagnostic values. We also established a dementia screening and assessment framework in clinical practice through systematic reviews and group consensus. It has improved the early diagnosis rate of dementia in China, been accepted by home and abroad academic institutions, which is of great significance for early diagnosis and treatment of dementia.

【Key words】Dementia; Screening and diagnostic; Framework

DOI：10.3760/cma.j.issn.0578-1426.2018.12.004

基金项目：中国工程院咨询研究项目（2017-ZD-06）；教育部/国家外国专家局高等学校学科创新引智计划（B08006）；教育部长江学者和创新团队发展计划（阿尔茨海默病）(IRT0810)

作者单位：100700 北京中医药大学东直门医院脑病科（田金洲、时晶、倪敬年）；解放军总医院南楼神经科（解恒革、王鲁宁）；北京医院神经内科（秦斌）；北京大学第三医院神经内科（樊东升）；北京中医药大学生命科学学院（卢涛）；北京大学第一医院神经内科（王荫华）

通信作者：田金洲，Email：jztian@hotmail.com