田金洲 解恆革 秦斌 樊東陞 盧濤 時晶 倪敬年 王魯寧 王蔭華

代錶中國老年保健協會 阿爾茨海默病分會研究小組

Dementia screening and diagnostic framework in Chinese population 

Tian Jinzhou*, Xie Hengge,Qin Bin, Fan Dongsheng, Lu Tao, Shi Jing, Ni Jingnian, Wang Luning, Wang Yinhua; The Research Group of Alzheimer′s Disease Chinese. *Neurology Center, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China

Corresponding author: Tian Jinzhou, Email: jztian@hotmail.com

【Summary】There are no standard diagnostic criteria for Alzheimer′s disease (AD) in China. The copied international criteria has led to a high rate of missed diagnosis due to issues such as translation and cultural discrepancy. Under the principles of semantic equivalence, content equivalence and performance equivalence, the research group of Alzheimer′s Disease Chinese ( ADC) adopted several effective methods, such as two-way translation, content conversion, performance evaluation, etc. to systematically study the cognitive, behavioral, functional, and general assessment techniques in dementia screening and diagnosis, as well as their screening thresholds and diagnostic values. We also established a dementia screening and assessment framework in clinical practice through systematic reviews and group consensus. It has improved the early diagnosis rate of dementia in China, been accepted by home and abroad academic institutions, which is of great significance for early diagnosis and treatment of dementia.

【Key words】Dementia; Screening and diagnostic; Framework

DOI：10.3760/cma.j.issn.0578-1426.2018.12.004

基金項目：中國工程院諮詢研究項目（2017-ZD-06）；教育部/國傢外國專傢局高等學校學科創新引智計劃（B08006）；教育部長江學者和創新糰隊髮展計劃（阿爾茨海默病）(IRT0810)

作者單位：100700 北京中醫藥大學東直門醫院腦病科（田金洲、時晶、倪敬年）；解放軍總醫院南樓神經科（解恆革、王魯寧）；北京醫院神經內科（秦斌）；北京大學第三醫院神經內科（樊東陞）；北京中醫藥大學生命科學學院（盧濤）；北京大學第一醫院神經內科（王蔭華）

通信作者：田金洲，Email：jztian@hotmail.com